The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond

@article{Berenbaum2016TheBA,
  title={The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond},
  author={Francis Berenbaum and Qing-Jun Meng},
  journal={Nature Reviews Rheumatology},
  year={2016},
  volume={12},
  pages={508-516}
}
Osteoarthritis (OA) is a prevalent and debilitating joint disease for which ageing, obesity and chronic inflammation are known risk factors. The central, peripheral and autonomic nervous systems are essential in all metabolic systems, and emerging evidence suggests a role for these systems in OA. In the past few years, metabolic diseases, such as obesity or diabetes, have been linked to disruption of circadian rhythms that are tightly regulated by the nervous system, whereas inflammatory and… CONTINUE READING

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