The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill

  title={The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill},
  author={Amy L Cilia La Corte and A. Carter and A. Turner and P. J. Grant and N. Hooper},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  pages={221 - 225}
  • Amy L Cilia La Corte, A. Carter, +2 authors N. Hooper
  • Published 2008
  • Medicine
  • Journal of the Renin-Angiotensin-Aldosterone System
  • Introduction. The renin-angiotensin and kininogen-kinin hormonal systems are critically involved in regulating blood pressure and are candidates in contributing to oral contraceptive pill (OCP)-induced hypertension.Angiotensin-converting enzyme (ACE) and aminopeptidase P (AP-P) are key enzymes in these systems and are both involved in the degradation of the vasodilator bradykinin. Methods. Circulating ACE and AP-P levels were measured by activity assay using selective fluorogenic peptide… CONTINUE READING
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