The bradykinin B1 receptor and the central regulation of blood pressure in spontaneously hypertensive rats.

@article{Emanueli1999TheBB,
  title={The bradykinin B1 receptor and the central regulation of blood pressure in spontaneously hypertensive rats.},
  author={Costanza Emanueli and Jean Chao and Domenico Regoli and Lee Chao and Aiguo Ni and Paolo Madeddu},
  journal={British journal of pharmacology},
  year={1999},
  volume={126 8},
  pages={1769-76}
}
1. We evaluated if the brain bradykinin (BK) B1 receptor is involved in the regulation of blood pressure (BP) in conscious rats. 2. Basal mean BP and HR were 115 +/- 2 and 165 +/- 3 mmHg and 345 +/- 10 and 410 +/- 14 beats min in Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR), respectively. Intracerebroventricular (i.c.v.) injection of 1 nmol B1 receptor agonist Lys-desArg9-BK significantly increased the BP of WKY and SHR by 7+/-1 and 19+/-2 mmHg, respectively. One nmol Sar[D-Phe8… CONTINUE READING
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