The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration.

@article{Hallgrmsson2006TheBM,
  title={The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration.},
  author={Benedikt Hallgr{\'i}msson and Jevon J Y Brown and Alice Fiona Ford-Hutchinson and H. David Sheets and Miriam L Zelditch and Frank Robert Jirik},
  journal={Evolution & development},
  year={2006},
  volume={8 1},
  pages={61-73}
}
Although it is well known that many mutations influence phenotypic variability as well as the mean, the underlying mechanisms for variability effects are very poorly understood. The brachymorph (bm) phenotype results from an autosomal recessive mutation in the phosphoadenosine-phosphosulfate synthetase 2 gene (Papps2). A major cranial manifestation is a dramatic reduction in the growth of the chondrocranium which results from undersulfation of glycosaminoglycans (GAGs) in the cartilage matrix… CONTINUE READING
39 Extracted Citations
50 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 39 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 50 references

Modern morphometrics

  • D. E. Slice
  • D. E. Slice (ed.). Modern Morphometrics in…
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…