The brachymorph mouse and the developmental‐genetic basis for canalization and morphological integration

  title={The brachymorph mouse and the developmental‐genetic basis for canalization and morphological integration},
  author={B. Hallgr{\'i}msson and Jevon J. Y. Brown and A. F. Ford-Hutchinson and H. D. Sheets and M. L. Zelditch and F. Jirik},
  journal={Evolution & Development},
  • B. Hallgrímsson, Jevon J. Y. Brown, +3 authors F. Jirik
  • Published 2006
  • Biology, Medicine
  • Evolution & Development
  • SUMMARY Although it is well known that many mutations influence phenotypic variability as well as the mean, the underlying mechanisms for variability effects are very poorly understood. The brachymorph (bm) phenotype results from an autosomal recessive mutation in the phosphoadenosine‐phosphosulfate synthetase 2 gene (Papps2). A major cranial manifestation is a dramatic reduction in the growth of the chondrocranium which results from undersulfation of glycosaminoglycans (GAGs) in the cartilage… CONTINUE READING
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