The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.

@article{Godin2009TheBH,
  title={The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.},
  author={Katherine S. Godin and H{\'e}l{\`e}ne Walbott and Nicolas Leulliot and Herman van Tilbeurgh and Gabriele Varani},
  journal={Journal of molecular biology},
  year={2009},
  volume={390 2},
  pages={231-44}
}
Box H/ACA small nucleolar (sno) ribonucleoproteins (RNPs) are responsible for the formation of pseudouridine in a variety of RNAs and are essential for ribosome biogenesis, modification of spliceosomal RNAs, and telomerase stability. A mature snoRNP has been reconstituted in vitro and is composed of a single RNA and four proteins. However, snoRNP biogenesis in vivo requires multiple factors to coordinate a complex and poorly understood assembly and maturation process. Among the factors required… CONTINUE READING