The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.

@article{Parker2000TheBP,
  title={The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.},
  author={Louise Parker and Seth D. Harris and Martin Gossen and Michael R Botchan},
  journal={Virology},
  year={2000},
  volume={270 2},
  pages={430-43}
}
Bovine papillomavirus type 1 (BPV-1) encodes two regulatory proteins, E1 and E2, that are essential for viral replication and transcription. E1, an ATP-dependent helicase, binds to the viral ori and is essential for viral replication, while the viral transcriptional activator, E2, plays cis-dominant roles in both viral replication and transcription. At low reporter concentrations, E1 stimulates E2 enhancer function, while at high reporter concentrations, repression results. An analysis of cis… CONTINUE READING