The bone mineral status of patients with marfan syndrome

  title={The bone mineral status of patients with marfan syndrome},
  author={Lynn A. Kohlmeier and Cheryll Gasner and Laura K. Bachrach and R Marcus},
  journal={Journal of Bone and Mineral Research},
Osteopenia at the hip and low total body calcium content have been reported in women with Marfan syndrome. Using dual X‐ray absorptiometry (DXA), we evaluated the lumbar spine L2‐L4 and proximal femur bone mineral density (BMD, g/cm2) in 32 women and 16 children with Marfan syndrome. The women were 38 ± 10 (SD) years old (23–58 years); their mean height was 178.6 ± 8 cm. The children (9 boys and 5 girls) were 9.9–17.5 years old. Children were tall for their ages but of normal weight. All… 

Bone mineral density in adults with Marfan syndrome.

Axial BMD is lower than normal in Marfan adults, and this reduction may contribute to fractures seen in the Marfan population.

Bone Mineral Density in Sixty Adult Patients with Marfan Syndrome

Both men and women with Marfan syndrome have a significant deficit of BMD at the hip and radius, and the decrease is present equally in both sexes and is more pronounced at predominantly cortical sites.

Assessment of bone mineral density in adults and children with Marfan syndrome

The results lead us to question the value of aggressive BMD evaluations by DXA in patients with diagnosed Marfan syndrome, particularly prior to reaching mid-age, as any application of bone mineral replacement therapy in these patients may be premature based on the existing evidence.

Assessment of Bone Mineral Status in Children With Marfan Syndrome

It is found that MFS patients have significantly lower BMC and BMD in whole body and lumbar spine, and larger longitudinal studies are required to evaluate the natural history, incidence of fractures, and effects of pharmacological therapy.

Bone mineral density in Marfan syndrome. A large case-control study.

Muscle and Bone Impairment in Children With Marfan Syndrome: Correlation With Age and FBN1 Genotype

  • Elsa HaineJ. Salles T. Edouard
  • Medicine, Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2015
It is recommended that measurement of bone mineral status should be part of the longitudinal clinical investigation of MFS children, and patients with a FBN1 premature termination codon mutation had a more severe musculoskeletal phenotype than patients with an inframe mutation.

Bone Mineral Density and Skeletal Manifestations in Patients with Sotos Syndrome

  • Medicine
  • 2020
Bone mineral density adjustment with bone age reflected the cohort’s bone profile more effectively than with height-age, as it was correlated significantly with urinary calcium excretion and osteocalcin, and could potentially have a prognostic value for skeletal health.

Antiretroviral Therapy and Bone Health

Significant correlations were observed between low BMD and increasing age and longer duration of ART but no relationship was observed with gender, therapy regimen or serum calcium or phosphate levels.



Bone mineral status of women with Marfan syndrome.

Osteoporosis in unstable adult scoliosis.

Changes were found in the youngest age groups, indicating reductions in bone mineral content earlier in the adult life of white women with a specific type of high-morbidity US characterized by the marker of lateral spondylolisthesis.

Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls.

Bone mineral apparent density (BMAD) is presented, which is BMC normalized to a derived bone reference volume, which minimizes the effect of bone geometry and allows comparisons of mineral status among bones of similar shape but different size.

Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures

Hip axis length predicts hip fractures independently of age and bone mineral density in elderly women and if verified by additional studies, can improve the assessment of hip fracture risk compared to a measurement of femoral neck bone density alone.

New approaches for interpreting projected bone densitometry data

  • D. CarterM. BouxseinR. Marcus
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1992
New analysis methods to reduce the confounding effect of bone size are described, and a parameter, bone mineral apparent density (BMAD, g/cm3), is introduced that better reflects bone apparent density.

Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome.

Prophylactic beta-adrenergic blockade is effective in slowing the rate of aortic dilatation and reducing the development of aortsic complications in some patients with Marfan's syndrome.

Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years

Skinfold thicknesses at four sites – biceps, triceps, subscapular and supra-iliac – and total body density were measured on 209 males and 272 females aged from 16 to 72 years, finding it necessary to use the logarithm of skinfold measurements in order to achieve a linear relationship with body density.

Location on chromosome 15 of the gene defect causing Marfan syndrome.

The chromosomal localization of the mutation in Marfan syndrome is a first step toward the isolation and characterization of the defective gene and serves as a diagnostic test in families in which cosegregation of these markers with the disease has been confirmed.

Rare inflammatory and hereditary connective tissue diseases.

The pregnant woman with the Marfan syndrome and pre-existing cardiovascular disease has a substantially increased risk of developing a major complication during gestation most commonly aortic aneurysm, dissection, rupture or insufficiency.