Corpus ID: 24880845

The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation.

@article{Charlesworth1996TheBR,
  title={The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation.},
  author={A. Charlesworth and S. Broad and E. Rozengurt},
  journal={Oncogene},
  year={1996},
  volume={12 6},
  pages={
          1337-45
        }
}
Bombesin elicits multiple signalling pathways in various cell types. It is not clear, however, whether these responses are mediated by a single receptor subtype or by different subtypes that couple preferentially to specific pathways. To resolve this we transfected the mouse bombesin/GRP receptor into Rat-1 fibroblasts and investigated the pathways activated by bombesin. Expression of the transfected receptors was verified by binding of (125I)GRP and two clones were selected, BOR5 and BOR15… Expand
Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway*
  • José L. Zugaza, Richard T. Waldron, James Sinnett-Smith, Enrique Rozengurt
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1997
EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.
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