The blowfly salivary gland - a model system for analyzing the regulation of plasma membrane V-ATPase.

@article{Baumann2012TheBS,
  title={The blowfly salivary gland - a model system for analyzing the regulation of plasma membrane V-ATPase.},
  author={O. Baumann and B. Walz},
  journal={Journal of insect physiology},
  year={2012},
  volume={58 4},
  pages={
          450-8
        }
}
Vacuolar H(+)-ATPases (V-ATPases) are heteromultimeric proteins that use the energy of ATP hydrolysis for the electrogenic transport of protons across membranes. They are common to all eukaryotic cells and are located in the plasma membrane or in membranes of acid organelles. In many insect epithelia, V-ATPase molecules reside in large numbers in the apical plasma membrane and create an electrochemical proton gradient that is used for the acidification or alkalinization of the extracellular… Expand
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TLDR
These findings suggest that the cAMP pathway mediates the reversible assembly and activation of V-ATPase molecules at the apical membrane upon hormonal stimulus. Expand
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TLDR
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