The blood platelets contribution to innate host defense - what they have learned from their big brothers.

  title={The blood platelets contribution to innate host defense - what they have learned from their big brothers.},
  author={Dorit M W Zander and Matthias Klinger},
  journal={Biotechnology journal},
  volume={4 6},
Bactericidal effects of blood platelets have been known for more than 120 years, but the underlying mechanisms are largely obscure. Keeping in mind structural and functional analogies of platelets to neutrophils, three different mechanisms are thinkable: Engulfment of pathogens, release of microbicidal proteins, and production of reactive oxygen species (ROS). Here, we focus on the release of ROS and a possible contribution of blood plasma and thrombin to the bactericidal effects. Killing of… CONTINUE READING
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