The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.

@article{Astradsson2009TheBB,
  title={The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.},
  author={Arnar Astradsson and Bruce G. Jenkins and Ji-Kyung Choi and Penelope J. Hallett and Michele A Levesque and Jack S McDowell and A G Brownell and Roger D. Spealman and O. Isacson},
  journal={Neurobiology of disease},
  year={2009},
  volume={35 3},
  pages={348-51}
}
It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the… CONTINUE READING
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Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

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