The blood-brain barrier and oncology: new insights into function and modulation.

@article{Bart2000TheBB,
  title={The blood-brain barrier and oncology: new insights into function and modulation.},
  author={Joost Bart and Harry J. M. Groen and N. Harry Hendrikse and Winette T A van der Graaf and Willem Vaalburg and Elisabeth G. E. de Vries},
  journal={Cancer treatment reviews},
  year={2000},
  volume={26 6},
  pages={449-62}
}
The efficacy of chemotherapy for malignant primary or metastatic brain tumours is still poor. This is at least partly due to the presence of the blood-brain barrier (BBB). The functionality of the BBB can be explained by physicochemical features and efflux pump mechanisms. An overview of the literature is presented with emphasis on oncology. The BBB consists of capillary endothelial cells that lack fenestrations and are connected together with continuous tight junctions, with a high electrical… CONTINUE READING

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