The blood-brain barrier: In vitro methods and toxicological applications.

  title={The blood-brain barrier: In vitro methods and toxicological applications.},
  author={I G Walker and Michael D Coleman},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={9 2},
The blood-brain barrier (BBB) is reviewed with reference to in vitro cell culture models and their use and potential use in toxicological studies. The structure, function and in vitro study of brain microvessel endothelial cells (BMEC) is briefly described, as well as the effects of a number of xenobiotics, such as solvents, metals, polycations and herbicides, on the viability and barrier function of the BBB model. The biotransformation of xenobiotics is increasingly thought to be responsible… CONTINUE READING

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