The blood-CSF barrier explained: when development is not immaturity.

  title={The blood-CSF barrier explained: when development is not immaturity.},
  author={Pia Annette Johansson and Katarzyna Magdalena Dziegielewska and Shane A Liddelow and Norman R Saunders},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={30 3},
It is often suggested that during development the brain barriers are immature. This argument stems from teleological interpretations and experimental observations of the high protein concentrations in fetal cerebrospinal fluid (CSF) and decreases in apparent permeability of passive markers during development. We argue that the developmental blood-CSF barrier restricts the passage of lipid-insoluble molecules by the same mechanism as in the adult (tight junctions) rendering the paracellular… CONTINUE READING

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