The blood–brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting

  title={The blood–brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting},
  author={Jorge Correale and Andr{\'e}s Mar{\'i}a Villa},
  pages={148 - 160}
In most regions of the central nervous system (CNS), the composition of the neuronal microenvironment is maintained by virtue of particular blood–brain-barrier (BBB) characteristics, to which vascular endothelial cells (ECs) contribute an important role. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS, characterized at tissue level by multifocal perivascular infiltrates, predominantly of lymphocytes and macrophages. Thus, lymphocyte recruitment into the brain across… 
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  • D. Begley
  • Biology
    Pharmacology & therapeutics
  • 2004
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