The blood–brain barrier: an overview Structure, regulation, and clinical implications
@article{Ballabh2004TheBB, title={The blood–brain barrier: an overview Structure, regulation, and clinical implications}, author={Praveen Ballabh and Alex Braun and Maiken Nedergaard}, journal={Neurobiology of Disease}, year={2004}, volume={16}, pages={1-13} }
1,812 Citations
Blood-Brain Barrier Dysfunction in the Detrimental Brain Function
- Biology
- 2021
This chapter will focus on the structure and function of the BBB and discuss how BBB breakdown causes detrimental brain function.
The Blood-Brain Barrier/Neurovascular Unit in Health and Disease
- BiologyPharmacological Reviews
- 2005
Understanding how BBB TJ might be affected by various factors holds significant promise for the prevention and treatment of neurological diseases.
Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
- BiologyPharmaceutics
- 2021
The fundamental structure and function of the blood-brain barrier is described in both healthy and altered/diseased conditions and the potential therapeutic targets that could be leveraged to restore the integrity of the BBB concomitant to the treatment of these brain disorders are provided.
Stroke Induced Blood-Brain Barrier Disruption
- BiologyAdvancement in the Pathophysiology of Cerebral Stroke
- 2019
This chapter emphasized recently gained information on BBB anatomy and its neuropathogenetic alteration in an ischemic cerebral injury.
Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches
- BiologyBrain Research Reviews
- 2010
Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases
- Biology, MedicineCardiovascular psychiatry and neurology
- 2011
Clinical and experimental evidence for the involvement of BBB dysfunction in the pathogenesis of seizures and epilepsy and important unresolved questions of how similar vascular dysfunction can lead to wide range of neurological symptoms and signs are tackled.
Exploring the Blood Brain Barrier: Structure, Function, and Medical Implications
- BiologyJournal of Student Research
- 2021
The structure and function of the blood brain barrier, including the variety of transport methods incorporated to maintain cerebral homeostasis, are discussed, and the capability of the SI protein on the SARS-CoV-2 virus to cross the bloodbrain barrier, causing encephalitis is detailed.
The Blood–Brain Barrier: An Introduction to Its Structure and Function
- Biology
- 2013
The blood-brain barrier (BBB) formed by the brains microvascular system is impermeable for most therapeutically used compounds and overcoming this barrier remains to be one of the big challenges in…
Basic physiology of the blood-brain barrier in health and disease: a brief overview
- BiologyTissue barriers
- 2020
This review aims to highlight the current knowledge on the cellular and molecular composition of the BBB with special emphasis on the major transport pathways across the barrier type endothelial cells and provides a discussion on the innovative brain drug delivery strategies in which the obstacle formed by BBB interferes with effective pharmacological treatment of neurodegenerative diseases/disorders.
References
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A range of interrelated pathways by which influences from the brain side or the blood side can modulate blood–brain barrier permeability are revealed, and pathways capable of reducing permeability hold promise for therapeutic treatment of inflammation and cerebral edema.
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It is concluded that intact neuronal or glial cells do not appear to be necessary for the maintenance in situ of the BBB properties examined herein.
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Direct evidence is provided that astrocytes are capable of inducing blood–brain barrier properties in non-neural endothelial cells in vivo.
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