The blood–brain barrier: an overview Structure, regulation, and clinical implications

@article{Ballabh2004TheBB,
  title={The blood–brain barrier: an overview Structure, regulation, and clinical implications},
  author={Praveen Ballabh and Alex Braun and Maiken Nedergaard},
  journal={Neurobiology of Disease},
  year={2004},
  volume={16},
  pages={1-13}
}
The blood-brain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds from blood to brain. Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end-feet, and pericytes (PCs). Tight junctions (TJs), present between the cerebral endothelial cells, form a diffusion barrier, which selectively excludes most blood-borne substances from entering the brain. Astrocytic end-feet tightly ensheath the vessel wall and appear to be critical… 
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