The blood–brain barrier: an overview: Structure, regulation, and clinical implications

  title={The blood–brain barrier: an overview: Structure, regulation, and clinical implications},
  author={P. Ballabh and A. Braun and M. Nedergaard},
  journal={Neurobiology of Disease},
  • P. Ballabh, A. Braun, M. Nedergaard
  • Published 2004
  • Biology, Medicine
  • Neurobiology of Disease
  • The blood-brain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds from blood to brain. Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end-feet, and pericytes (PCs). Tight junctions (TJs), present between the cerebral endothelial cells, form a diffusion barrier, which selectively excludes most blood-borne substances from entering the brain. Astrocytic end-feet tightly ensheath the vessel wall and appear to be critical… CONTINUE READING
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