The blood–brain barrier: an overview: Structure, regulation, and clinical implications

@article{Ballabh2004TheBB,
  title={The blood–brain barrier: an overview: Structure, regulation, and clinical implications},
  author={P. Ballabh and A. Braun and M. Nedergaard},
  journal={Neurobiology of Disease},
  year={2004},
  volume={16},
  pages={1-13}
}
  • P. Ballabh, A. Braun, M. Nedergaard
  • Published 2004
  • Biology, Medicine
  • Neurobiology of Disease
  • The blood-brain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds from blood to brain. Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end-feet, and pericytes (PCs). Tight junctions (TJs), present between the cerebral endothelial cells, form a diffusion barrier, which selectively excludes most blood-borne substances from entering the brain. Astrocytic end-feet tightly ensheath the vessel wall and appear to be critical… CONTINUE READING
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    • 197
    • Highly Influenced
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 149 REFERENCES
    Astrocytes induce blood–brain barrier properties in endothelial cells
    • 1,476
    Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability
    • 648
    Role of the CNS microvascular pericyte in the blood‐brain barrier
    • 292
    Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation.
    • 319
    • Highly Influential
    • PDF
    Early ultrastructural changes in blood-brain barrier vessels of the rat embryo.
    • 80
    • Highly Influential
    Angiogenesis of the blood‐brain barrier in vitro and the function of cerebral pericytes
    • 164
    Re‐evaluating the role of astrocytes in blood‐brain barrier induction
    • 90