The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

@article{Engelhardt2009TheBA,
  title={The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction},
  author={Britta Engelhardt and Lydia Sorokin},
  journal={Seminars in Immunopathology},
  year={2009},
  volume={31},
  pages={497-511}
}
The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid plexus epithelial cells. The BBB inhibits the free paracellular diffusion of water-soluble molecules by an elaborate network of complex tight junctions (TJs) that interconnects… CONTINUE READING
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