The blessings and curses of intestinal inflammation.

@article{Winter2010TheBA,
  title={The blessings and curses of intestinal inflammation.},
  author={Sebastian E Winter and A. Keestra and R. Tsolis and A. B{\"a}umler},
  journal={Cell host & microbe},
  year={2010},
  volume={8 1},
  pages={
          36-43
        }
}
  • Sebastian E Winter, A. Keestra, +1 author A. Bäumler
  • Published 2010
  • Medicine, Biology
  • Cell host & microbe
  • The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the lumenal secretion of antimicrobial peptides, as well as the release of cytokines in tissue that recruit and activate phagocytes. However, pathogens have evolved to utilize these environmental changes in the inflamed… CONTINUE READING

    Figures and Topics from this paper.

    Shigella deploy multiple countermeasures against host innate immune responses.
    45
    A breathtaking feat
    40
    Dietary rice bran promotes resistance to Salmonella enterica serovar Typhimurium colonization in mice
    35
    Pathogens, microbiome and the host: emergence of the ecological Koch's postulates
    37

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 82 REFERENCES
    Motility allows S. Typhimurium to benefit from the mucosal defence
    152
    Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota
    777
    Enteric defensins are essential regulators of intestinal microbial ecology
    880
    Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.
    676
    The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation.
    139