The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

@article{Moeller2008TheBA,
  title={The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?},
  author={Antje Moeller and Kjetil Ask and David Warburton and Jack Gauldie and Martin Kolb},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 3},
  pages={362-82}
}
Different animal models of pulmonary fibrosis have been developed to investigate potential therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model in rodents (mouse, rat and hamster). Over the years, numerous agents have been shown to inhibit fibrosis in this model. However, to date none of these compounds are used in the clinical management of IPF and none has shown a comparable antifibrotic effect in humans. We performed a systematic review of publications on… CONTINUE READING
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