The bistable network model of brain ischemia

@inproceedings{Hossmann2010TheBN,
  title={The bistable network model of brain ischemia},
  author={Konstantin Alexander Hossmann},
  year={2010}
}
In a set of four interconnected papers DeGracia presents a novel network-based explanatory framework for conceptualizing the outcome of ischemic injury that deviates sharply from the currently prevailing approach of linear injury superposition. The thorough analysis of the increasing use of network theory in modern biology pro-vides the background for envisioning a new chapter of brain ischemia research which may be able to overcome the present dilemma of stroke treatment. 
1 Citations
Mechanisms of translation arrest following focal brain ischemia
TLDR
This document summarizes the findings of a post-mortem examination conducted at the Mayo Clinic in Rochester, Minnesota, in order to establish the cause and manner in which the patient's death was caused by multiple causes. Expand

References

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Towards a dynamical network view of brain ischemia and reperfusion. Part IV: additional considerations.
  • D. DeGracia
  • Medicine
  • Journal of experimental stroke & translational medicine
  • 2010
TLDR
Here a first look at applying the bistable model to focal cerebral ischemia is offered, and initial considerations of the network architecture underlying the post-ischemic state space are discussed. Expand
Towards a dynamical network view of brain ischemia and reperfusion. Part I: background and preliminaries.
  • D. DeGracia
  • Medicine
  • Journal of experimental stroke & translational medicine
  • 2010
TLDR
It is concluded that all changes induced in the brain by ischemia can be classified as either damage mechanisms that contribute to cell death, or stress responses that contributeto cell survival. Expand
Towards a dynamical network view of brain ischemia and reperfusion. Part II: a post-ischemic neuronal state space.
  • D. DeGracia
  • Medicine
  • Journal of experimental stroke & translational medicine
  • 2010
TLDR
The second in a series of four papers whose purpose is to work towards a revision of the concept of brain ischemia by applying network concepts to develop a bistable model of brainIschemia is built, which is that of a post-ischemic state space. Expand
Towards a dynamical network view of brain ischemia and reperfusion. Part III: therapeutic implications.
  • D. DeGracia
  • Medicine
  • Journal of experimental stroke & translational medicine
  • 2010
TLDR
It is illustrated that the bistable model provides a viable alternative to the ischemic cascade as an explanatory framework and as a guide for therapeutic development. Expand
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Several of the key topics, particularly those in basic science stroke research and imaging, span prevention, therapy and recovery, thus conceivably making contributions to multiple areas of stroke management, are presented. Expand
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