The bisphosphonate zoledronic acid effectively targets lung cancer cells by inhibition of protein prenylation.

@article{Xie2015TheBZ,
  title={The bisphosphonate zoledronic acid effectively targets lung cancer cells by inhibition of protein prenylation.},
  author={Fan Xie and Pengcheng Li and Jianhua Gong and Jiahong Zhang and J Ma},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={467 4},
  pages={664-9}
}
Aberrant activation of oncoproteins such as members of the Ras family is common in human lung cancers. The proper function of Ras largely depends on a post-translational modification termed prenylation. Bisphosphonates have been shown to inhibit prenylation in cancer cells. In this study, we show that zoledronic acid, a third generation bisphosphonate, is effective in targeting lung cancer cells. This is achieved by the induction of apoptosis and inhibition of proliferation, through suppressing… CONTINUE READING