The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats.

@article{Kurth2005TheBI,
  title={The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats.},
  author={Andreas H. A. Kurth and Christian Eberhardt and Stefan M{\"u}ller and Michael Steinacker and Markus Schwarz and F E - Roche Bauss},
  journal={Bone},
  year={2005},
  volume={37 2},
  pages={204-10}
}
Osteoporosis is known to impair the process of implant osseointegration. Bisphosphonates are drugs that inhibit osteoclast-mediated bone resorption and normalize the high rate of bone turnover that characterizes this disease. Consequently, there is a rationale for using bisphosphonates to enhance the early stabilization of implants in subjects with low bone mass. In this study, 84 rats received titanium-only or hydroxyapatite (HA)-coated titanium femoral implants, 3 months after being… CONTINUE READING
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