The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer.

@article{Yang2011TheBR,
  title={The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer.},
  author={Gong Yang and Xue Sherry Xiao and Daniel Gustavo Rosen and Xi Cheng and Xiaohua Wu and Bin Chang and Guangzhi Liu and Fengxia Xue and I Mercado-uribe and Paul J. Chiao and Xiang Du and Jinsong Liu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 8},
  pages={2181-94}
}
PURPOSE NF-κB is a transcription factor known to promote tumorigenesis. However, NF-κB is also known to be proapoptotic and may potentially function as a tumor suppressor, although such a functional role has not been extensively investigated in human cancer. EXPERIMENTAL DESIGN A dominant-negative mutant of IκBα with mutations at S32A and S36A was used to inhibit the function of NF-κB in ovarian cancer cell lines. The transcription ability, tumorigenesis, apoptosis, and drug sensitivity were… CONTINUE READING