The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats.

@article{Bakaya1997TheBO,
  title={The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats.},
  author={Mustafa K Başkaya and A. Maruthi Rao and Aclan Dogan and David S Donaldson and Robert J Dempsey},
  journal={Neuroscience letters},
  year={1997},
  volume={226 1},
  pages={33-6}
}
This study examined the time course of the blood-brain barrier (BBB) opening and correlated this with brain edema formation after a lateral controlled cortical impact (CCI) brain injury in rats. Quantitative measurement of Evans blue (EB) extravasation using fluorescence was employed at 2, 4, 6 h and 1, 2, 3, 4 and 7 days after injury. Brain edema was measured by specific gravity of the tissue at corresponding time points. Two prominent EB extravasations were observed at 4-6 h and 3-day after… CONTINUE READING
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