The biphasic calcium dose-response curve for parathyroid hormone secretion in electropermeabilized adult bovine parathyroid cells.

We have used the method of electropermeabilization to measure the dependence of PTH secretion on internal calcium concentration in adult bovine parathyroid cells. The dose-response curve is biphasic, with a peak at 10(-7) M calcium. This result differs significantly from the dose-response curves that have been determined by this method for many other… CONTINUE READING