The biphasic behavior of incoherent feed-forward loops in biomolecular regulatory networks.

@article{Kim2008TheBB,
  title={The biphasic behavior of incoherent feed-forward loops in biomolecular regulatory networks.},
  author={Dongsan Kim and Yung-Keun Kwon and Kwang-Hyun Cho},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2008},
  volume={30 11-12},
  pages={1204-11}
}
An incoherent feed-forward loop (FFL) is one of the most-frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a 'fast activation and delayed inhibition'. We find that the dynamics of various incoherent FFLs can be further classified into two types: time-dependent biphasic responses and dose-dependent biphasic responses. Why do the structurally identical incoherent FFLs play such… CONTINUE READING

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