The biotin repressor: modulation of allostery by corepressor analogs.

  title={The biotin repressor: modulation of allostery by corepressor analogs.},
  author={P. Brown and J. Cronan and M. Gr{\o}tli and D. Beckett},
  journal={Journal of molecular biology},
  volume={337 4},
  • P. Brown, J. Cronan, +1 author D. Beckett
  • Published 2004
  • Biology, Medicine
  • Journal of molecular biology
  • The Escherichia coli biotin repressor functions in biotin retention and regulation of biotin biosynthesis. Biotin retention is accomplished via the two-step biotinylation of the biotin-dependent enzyme, acetyl-CoA carboxylase. In the first step of this reaction the substrates biotin and ATP are utilized in synthesis of the activated biotin, biotinyl-5'-AMP, while in the second step this activated biotin is transferred to a unique lysine residue of the biotin carboxyl carrier protein subunit of… CONTINUE READING
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