The biosynthetic origin of psychoactive kavalactones in kava

@article{Pluskal2018TheBO,
  title={The biosynthetic origin of psychoactive kavalactones in kava},
  author={Tom{\'a}{\vs} Pluskal and Michael Patrick Torrens-Spence and Timothy R. Fallon and Andrea De Abreu and Cindy H. Shi and Jing‐Ke Weng},
  journal={Nature Plants},
  year={2018},
  pages={1-12}
}
Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and difficulty in chemical synthesis hinder the therapeutic use of kavalactones. In addition, kava also… 

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