The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90.

@article{Molnr2000TheBG,
  title={The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90.},
  author={Istv{\'a}n Moln{\'a}r and Thomas Schupp and Michiyuki Ono and Ross Zirkle and Maureen Milnamow and Brian Nowak-Thompson and Nora Engel and C. Toupet and Ansgar Stratmann and Devon D Cyr and Joern Gorlach and J M Calbo Mayo and An Fu Hu and Stephen P Goff and Jan Schmid and James M. Ligon},
  journal={Chemistry & biology},
  year={2000},
  volume={7 2},
  pages={97-109}
}
BACKGROUND Epothilones are produced by the myxobacterium Sorangium cellulosum So ce90, and, like paclitaxel (Taxol((R))), they inhibit microtubule depolymerisation and arrest the cell cycle at the G2-M phase. They are effective against P-glycoprotein-expressing multiple-drug-resistant tumor cell lines and are more water soluble than paclitaxel. The total synthesis of epothilones has been achieved, but has not provided an economically viable alternative to fermentation. We set out to clone… CONTINUE READING

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