The biosynthesis of 3β‐hydroxy‐5,7‐androstadien‐17‐one by the horse fetal gonad

  title={The biosynthesis of 3$\beta$‐hydroxy‐5,7‐androstadien‐17‐one by the horse fetal gonad},
  author={Alexander D. Tait and L. C. Hodge and W. Ross Allen},
  journal={FEBS Letters},

Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives.

  • M. ŻmijewskiWei Li A. Slominski
  • Biology
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2008
Calcitriol (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-1alpha,3beta,25-triol) is a powerful oncostatic form of vitamin D3 that is of limited clinical utility due to hypercalcemic (toxic)

Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin

7DHP, its photoderivative 20-oxopregnacalciferol, and pregnenolone exhibited biological activity in skin cells including inhibition of proliferation of epidermal keratinocytes and melanocytes, and melanoma cells.

Postnatal decline in gonadal secretion of dehydroepiandrosterone and 3 beta-hydroxyandrosta-5,7-dien-17-one in the newborn foal.

It was concluded that DHEA is the major steroid produced by the gonads at birth and the mechanism and significance of the apparent abrupt decline in gonadal steroidogenesis in the newborn foal remain unknown.

Novel vitamin D photoproducts and their precursors in the skin

Main products of CYP11A1-mediated metabolism on vitamin D are non-calcemic and non-toxic at relatively high doses and serve as partial agonists on the vitamin D receptor.

Peripartal endocrinology in the mare and foetus.

  • J. Ousey
  • Medicine, Biology
    Reproduction in domestic animals = Zuchthygiene
  • 2004
The endocrine profiles in the periparturient mares are dominated by increasing concentrations of progestagens and decreasing oestrogens, and the biological role of the various hormones present in pregnant mares is established, in particular, those hormones which control myometrial quiescence.



Formation of steroids by the pregnant mare. 3. Metabolism of 14C-squalene and 3H-dehydroisoandrosterone injected into the fetal circulation.

It is demonstrated that ring B unsaturated estrogens are formed independently of the classical pathway of biosynthesis and that a bifurcation occurs at a point prior to the formation of squalene.

The chromatography of Steroids, pp.358-371

  • J. Org. Chem. 16,
  • 1973