The biosynthesis and regulation of bacterial prodiginines

@article{Williamson2006TheBA,
  title={The biosynthesis and regulation of bacterial prodiginines},
  author={Neil R. Williamson and Peter C. Fineran and Finian J Leeper and George P. C. Salmond},
  journal={Nature Reviews Microbiology},
  year={2006},
  volume={4},
  pages={887-899}
}
The red-pigmented prodiginines are bioactive secondary metabolites produced by both Gram-negative and Gram-positive bacteria. Recently, these tripyrrole molecules have received renewed attention owing to reported immunosuppressive and anticancer properties. The enzymes involved in the biosynthetic pathways for the production of two of these molecules, prodigiosin and undecylprodigiosin, are now known. However, the biochemistry of some of the reactions is still poorly understood. The physiology… CONTINUE READING
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