The biomass objective function.

Abstract

Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.

DOI: 10.1016/j.mib.2010.03.003

3 Figures and Tables

0501002011201220132014201520162017
Citations per Year

451 Citations

Semantic Scholar estimates that this publication has 451 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Feist2010TheBO, title={The biomass objective function.}, author={Adam M. Feist and Bernhard O. Palsson}, journal={Current opinion in microbiology}, year={2010}, volume={13 3}, pages={344-9} }