The biology of the opioid growth factor receptor (OGFr)

@article{Zagon2002TheBO,
  title={The biology of the opioid growth factor receptor (OGFr)},
  author={Ian S. Zagon and Michael F Verderame and Patricia J. McLaughlin},
  journal={Brain Research Reviews},
  year={2002},
  volume={38},
  pages={351-376}
}
Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving for neurotransmission/neuromodulation in the nervous system. The native opioid growth factor (OGF), [Met(5)]-enkephalin, is a tonic inhibitory peptide that plays a role in cell proliferation and tissue organization during development, cancer, cellular renewal, wound healing, and angiogenesis. OGF action is mediated by a receptor mechanism. Assays with radiolabeled OGF have detected specific… 
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TLDR
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