The biology of stem cell factor, a new hematopietic growth factor involved in stem cell regulation

@article{Galli1993TheBO,
  title={The biology of stem cell factor, a new hematopietic growth factor involved in stem cell regulation},
  author={Matilde Callari Galli and Patricia J. Giardina and Anna Rita Migliaccio and Giovanni Ciro Migliaccio},
  journal={International Journal of Clinical and Laboratory Research},
  year={1993},
  volume={23},
  pages={70-77}
}
SummaryRecently, a new hematopoietic growth factor, stem cell factor, the ligand for the c-kit-proto-oncogene, has been cloned. The gene for this factor or for its receptor are deleted in two well know series of mice mutants which display pleiotropic stem cell defects. Therefore, this factor supposedly plays an important role in stem cell biology. This paper reviews some of the elegant genetic work which led to the discovery of the factor and of its receptor, the biological effects that this… CONTINUE READING