The biology of leptin: a review.

@article{Houseknecht1998TheBO,
  title={The biology of leptin: a review.},
  author={Karen L Houseknecht and Clifton A. Baile and Robert L. Matteri and Michael E. Spurlock},
  journal={Journal of animal science},
  year={1998},
  volume={76 5},
  pages={
          1405-20
        }
}
Leptin, a 16-kDa protein secreted from white adipocytes, has been implicated in the regulation of food intake, energy expenditure, and whole-body energy balance in rodents and humans. The gene encoding leptin was identified by positional cloning and is the mutation leading to the profound obese phenotype of the ob/ob mouse. Exogenous administration of leptin to ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss. The… 
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