The biology of interleukin-5 and its receptor.

  title={The biology of interleukin-5 and its receptor.},
  author={Siddhartha Mahanty and T B Nutman},
  journal={Cancer investigation},
  volume={11 5},
IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites and a diverse group of hypereosinophilic conditions of no known etiology. Our understanding of the biological role of IL-5 in the regulation of… CONTINUE READING

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