The biology of innate lymphoid cells

  title={The biology of innate lymphoid cells},
  author={David Artis and Hergen Spits},
The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over… 

The Innate Lymphoid Cell Precursor.

Advances in mapping the emergence of these lineages from early lymphoid precursors are reviewed, including the identification of a common innate lymphoid cell precursor characterized by transient expression of the transcription factor PLZF, and the lineage relationships of innate lymphoids cells with conventional natural killer cells and lymphoid tissue inducer cells are reviewed.

Innate lymphoid cell regulation of adaptive immunity

This review will focus initially on the current understanding of where ILC populations are located and what this means for potential cellular interactions, and mechanisms underpinning such interactions and how they may contribute to controlling adaptive immunity will be considered.

Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis

This review will explore the functions of ILCs and other cells in maintaining gut homeostasis and feature the crosstalk between I LCs with other cells and potential pharmacotherapy targeting ILC’s applicable in intestinal innate immunity.

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

This Review highlights experimental evidence from mouse models and patient-based studies that have elucidated the effects of ILCs on the maintenance of tissue homeostasis and the consequences for health and disease.

The development of adult innate lymphoid cells.

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

How current or novel therapeutic strategies could be used to selectively modulate ILC responses and limit chronic inflammatory diseases is discussed.

Activation and Function of Innate Lymphoid Cells

Efferent innate immune responses include the function of innate lymphoid cells, a previously unappreciated cell type of the innate immune system that has been characterized in mice and humans and

Stem Cell Therapy and Innate Lymphoid Cells

In this review, an attempt has been made to provide current information related to NK and ILCs cell-based stem cell therapies and role of the stem cells in the regulation of I LCs as well.

Innate lymphocytes—lineage, localization and timing of differentiation

Light is shed on the identities of innate lymphocytes through the lenses of cell lineage, localization, and timing of differentiation in tissue-resident innate lymphoid cells.



The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

Research has identified what can be considered a family of innate lymphoid cells (ILCs) that includes not only natural killer (NK) cells and lymphoid tissue–inducer (LTi) cells but also cells that

Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice

This work sought to investigate the capacity of ILC2s to regulate effector functions of T cells in innate lymphoid cells and found it to be able to mediate the immune pathology of asthma even without adaptive immunity.

Regulation of Adaptive Immunity by the Innate Immune System

Questions are discussed including the mechanisms by which pathogen-specific innate immune recognition activates antigen-specific adaptive immune responses and the roles of different types of innate immune Recognition in host defense from infection and injury.

A committed hemopoietic precursor to innate lymphoid cells

A novel subset of lymphoid precursors in mouse fetal liver and adult bone marrow that transiently express high amounts of PLZF, a transcription factor previously associated with NK T cell development, is identified and identified, establishing novel lineage relationships between ILC, NK and LTi cells, and identifying the common precursor to ILCs, termed ILCP.

Lineage Relationship Analysis of RORγt+ Innate Lymphoid Cells

This study indicates that RORγt+ ILCs evolve to preempt intestinal colonization by microbial symbionts and are favored that play a role in intestinal defense before the gut is fully colonized by intestinal microbiota.

Innate lymphoid cells regulate CD4+ T cell responses to intestinal commensal bacteria

It is identified that ILCs maintain intestinal homeostasis through MHCII-dependent interactions with CD4+ T cells that limit pathological adaptive immune cell responses to commensal bacteria.

Innate lymphoid cells — a proposal for uniform nomenclature

It is proposed that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing I LC1 cells in the pathogenesis of gut mucosal inflammation.

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Evidence is provided that the transcription factor T-bet determines the fate of a distinct lineage of CCR6−RORγt+ ILCs, a type of innate lymphocyte population required for immunity to intestinal infections, which is essential for the release of mucus-forming glycoproteins required to protect the epithelial barrier during Salmonella enterica infection.