The biology of hair follicles.

  title={The biology of hair follicles.},
  author={Ralf Paus and George Cotsarelis},
  journal={The New England journal of medicine},
  volume={341 7},
Hair has many useful biologic functions, including protection from the elements and dispersion of sweat-gland products (e.g., pheromones). It also has psychosocial importance in our society, and patients with hair loss (alopecia) (Table 1) or excessive hair growth often suffer tremendously. Not surprisingly, the demand for drugs that alter hair growth and appearance has led to a multibillion-dollar industry, yet few drugs that are effective for these purposes are available. However, recent… 

The Hedgehog and the hair follicle: a growing relationship.

  • A. Dlugosz
  • Environmental Science
    The Journal of clinical investigation
  • 1999
Given the recent progress in elucidating some of the signals regulating hair follicle growth and development, there is hope that more useful therapies may soon be available.

Biology of human hair: know your hair to control it.

General aspects of hair biology are reviewed, as well as the most recent contributions to understanding hair pigmentation and the regulation of hair development, indicating methods for genetic/biochemical modulation of HF components for the treatment of hair diseases.

Anatomy and Physiology of Hair

Distinctive anatomy and physiology of hair follicle are presented in this chapter and can contribute to understand and heal different hair disorders.

[Diseases of hair].

  • H. WolffH. Merk
  • Medicine
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 2013
The care, preservation, and fashionable dressing of the hair of the head and beard are important for esthetic and social reasons and can affect interpersonal relationships and can create considerable psychological disturbances.

EEMCO Guidance for the Assessment of Hair Shedding and Alopecia

Clinical evaluations benefit from a few additional specific techniques that enhance the perception of hair (re-) growth, shedding and alopecia, especially when the hair loss is accompanied by scarring.

The genetically programmed hair growth cycle and alopecia: what is there to know?

The last 20 years have seen a vast change in research activity into the regulation of hair growth in health and disease and, over the next 5 years, this should include further important glimpses of the nature of the hair follicle's clock machinery.

Herbal preparations for the treatment of hair loss

The plants with the most evidence-based effect against alopecia are Curcuma aeruginosa (pink and blue ginger), Serenoa repens (palmetto), Cucurbita pepo (pumpkin), Trifolium pratense (red clover), and Panax ginseng (Chinese red ginsenge).

Exploring the potential of herbal drugs for the treatment of hair loss

In present article, information about loss of hair loss, types of alopecia, causes and various medicinal plants and parts they’re of used in treatment prophylaxis or treatment ofhair loss are covered.

Drug that Causes Hair Loss and Promotes Hair Growth-A Review

The difficult task in diagnosing hair and hair disorders is to distinguish between a true disorder and a subjective complaint and to analyze the underlying pathogenesis.



Clinical updates in hair.

  • M. Sawaya
  • Medicine, Biology
    Dermatologic clinics
  • 1997

Hair follicle growth controls.

The feasibility of targeted selective gene therapy of the hair follicle

The selective targeting of the lacZ reporter gene to the hair follicles in mice after topical application of the gene entrapped in liposomes demonstrates that highly selective, safe gene therapy for the hair process is feasible.

Towards defining the pathogenesis of the hairless phenotype.

Hairless mice offer a unique model for dissecting the as yet obscure functional properties of the hr gene product in maintaining follicle integrity during normal catagen, and it is proposed that dermal cysts in hr skin arise from (i) the central ORS, (ii) bulge-derived cells, or (iii) the disintegrating proximal ORS under the influence of dermal papilla remnants.

Biochemical mechanisms regulating human hair growth.

  • M. Sawaya
  • Biology, Medicine
    Skin pharmacology : the official journal of the Skin Pharmacology Society
  • 1994
Kinetic constants have been evaluated for several enzymes which mediate dihydrotestosterone formation, including 5a-reductase, and the cytochrome P-450 aromatase enzyme in isolated human hair follicles and sebaceous glands from scalp of men and women with androgenetic alopecia, indicating that similar steroid mechanisms may be taking place in men andWomen, but the amount or level of enzymes vary.

Neural mechanisms of hair growth control.

It is suggested that the study of piloneural interactions promises important insights into general principles of neuroepithelial communication, namely during epithelial morphogenesis and remodeling, as well as targeted manipulations for managing hair growth disorders.

Disorders of hair growth : diagnosis and treatment

This book discusses the embryology and anatomy of the hair follicle, clinical tools for assessing hair growth, and the genetic and physical causes of hair loss, and scalp conditions of significance.