The biology of caveolae: lessons from caveolin knockout mice and implications for human disease.

@article{Hnasko2003TheBO,
  title={The biology of caveolae: lessons from caveolin knockout mice and implications for human disease.},
  author={Robert Hnasko and Michael Phillip Lisanti},
  journal={Molecular interventions},
  year={2003},
  volume={3 8},
  pages={445-64}
}
Caveolae, plasma membrane invaginations that serve as membrane organizing centers, are found in most cell types, but are enriched in adipocytes, endothelial cells, and myocytes. Three members of the caveolin family (Cav-1, -2, and -3) are essential for the formation of caveolae. Specialized motifs in the caveolin proteins function to recruit lipids and proteins to caveolae for participation in intracellular trafficking of cellular components and operation in signal transduction. Mutations in… CONTINUE READING
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