The biology of YAP/TAZ: hippo signaling and beyond.

  title={The biology of YAP/TAZ: hippo signaling and beyond.},
  author={Stefano Piccolo and Sirio Dupont and Michelangelo Cordenonsi},
  journal={Physiological reviews},
  volume={94 4},
The transcriptional regulators YAP and TAZ are the focus of intense interest given their remarkable biological properties in development, tissue homeostasis and cancer. YAP and TAZ activity is key for the growth of whole organs, for amplification of tissue-specific progenitor cells during tissue renewal and regeneration, and for cell proliferation. In tumors, YAP/TAZ can reprogram cancer cells into cancer stem cells and incite tumor initiation, progression and metastasis. As such, YAP/TAZ are… CONTINUE READING
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