The biology of VEGF and its receptors

@article{Ferrara2003TheBO,
  title={The biology of VEGF and its receptors},
  author={Napoleone Ferrara and Hans-Peter Gerber and Jennifer Lecouter},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={669-676}
}
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF… 
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