The biology of TNF blockade.

  title={The biology of TNF blockade.},
  author={Arun G Suryaprasad and Thomas Prindiville},
  journal={Autoimmunity reviews},
  volume={2 6},
Rheumatoid arthritis and Crohn's disease are costly diseases that result in significant long-term patient disability. They are chronic inflammatory diseases that are associated with increased production of Tumor Necrosis Factor (TNF). Blockage of this cytokine with bio-engineered compounds has significantly changed therapy of these diseases and has ushered in the era of biological therapy. The pro-inflammatory role of TNF is mediated by its essential respiratory burst function that is… CONTINUE READING