The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications.

@article{Yan2007TheBO,
  title={The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications.},
  author={Shi Fang Yan and Gaetano Barile and Vivette D D'agati and Shi Du Yan and Ravichandran Ramasamy and Ann Marie Schmidt},
  journal={Current diabetes reports},
  year={2007},
  volume={7 2},
  pages={146-53}
}
The interaction of glucose-modified and inflammation-promoting ligands with the receptor for advanced glycation end products (RAGE) is emerging as a central mechanism contributing to the diverse complications of diabetes. These ligands, particularly in oligomeric form, bind to RAGE and transduce intracellular signals. The consequences of this interaction, as elucidated in cultured cells and animal models, include upregulation of inflammatory and tissue-degradative pathways. Pharmacologic… CONTINUE READING

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