The biology of IGE and the basis of allergic disease.

  title={The biology of IGE and the basis of allergic disease.},
  author={Hannah J Gould and Brian J. Sutton and Andrew J Beavil and Rebecca L. Beavil and Natalie McCloskey and Heather A. Coker and David Fear and Lyn Smurthwaite},
  journal={Annual review of immunology},
Allergic individuals exposed to minute quantities of allergen experience an immediate response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast cells by allergen-specific IgE antibodies bound to their high-affinity receptors (FcepsilonRI). A combination of factors contributes to such long-lasting sensitization of the mast cells. They include the homing of mast cells to mucosal tissues, the local synthesis of IgE, the induction of FcepsilonRI expression on mast… CONTINUE READING
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