The biology behind the human intervertebral disc and its endplates.
@article{Tomaszewski2015TheBB, title={The biology behind the human intervertebral disc and its endplates.}, author={Krzysztof A. Tomaszewski and Karolina Saganiak and Tomasz Gładysz and Jerzy A. Walocha}, journal={Folia morphologica}, year={2015}, volume={74 2}, pages={ 157-68 } }
The intervertebral discs (IVDs) are roughly cylindrical, fibrocartilaginous, articulating structures connecting the vertebral bodies, and allowing movement in the otherwise rigid anterior portion of the vertebral column. They also transfer loads and dissipate energy. Macroscopically the intervertebral disc can be divided into an outer annulus fibrosus surrounding a centrally located nucleus pulposus. The endplates surround the IVD from both the cranial and caudal ends, and separate them from…
25 Citations
Validation of the intervertebral disc histological degeneration score in cervical intervertebral discs and their end plates.
- MedicineThe spine journal : official journal of the North American Spine Society
- 2017
Development, Pathogenesis, and Regeneration of the Intervertebral Disc: Current and Future Insights Spanning Traditional to Omics Methods
- Biology, MedicineFrontiers in Cell and Developmental Biology
- 2022
Current knowledge base on IVD development, degeneration, and regenerative strategies taken from traditional genetic approaches and omics studies are summarized and the future landscape of investigations in IVD research and advancement of clinical therapies are discussed.
Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs
- BiologyCell and Tissue Research
- 2019
Mechanobiological studies of IVD cells (specifically, annulus fibrosus and nucleus pulposus cells) are compiled and synthesized and discussed the key findings of the field.
The influence of artificial nucleus pulposus replacement on stress distribution in the cartilaginous endplate in a 3-dimensional finite element model of the lumbar intervertebral disc
- Engineering, BiologyMedicine
- 2017
Evidence is provided suggesting that NP replacement, vertebral stress, and bulging displacement are lower than that of degenerative IVD and IVD with NP removal under different motion states.
Intervertebral disc decellularisation: progress and challenges.
- Biology, MedicineEuropean cells & materials
- 2021
The studies reviewed support the notion that tissue-engineering-based strategies resorting to decellularised IVD may represent a major advancement in the treatment of disc degeneration and consequent LBP.
The Endplate Role in Degenerative Disc Disease Research: The Isolation of Human Chondrocytes from Vertebral Endplate—An Optimised Protocol
- Biology, MedicineBioengineering
- 2022
A relatively quick and easy protocol for isolating human chondrocytes from the vertebral endplates will permit the study of cell properties, biochemical aspects, the potential of therapeutic candidates for the treatment of disc degeneration, and toxicology studies in a well-controlled environment.
Age- and degeneration-related variations in cell density and glycosaminoglycan content in the human cervical intervertebral disc and its endplates.
- Biology, EngineeringPolish journal of pathology : official journal of the Polish Society of Pathologists
- 2015
Detailed 3D maps of cervical IVD and endplate cell density and GAG content are introduced and it shows that cervical IVDs and their endplates only slightly differ, in terms of celldensity and G AG content, from lumbar IVDs.
Tissue-Engineering of Human Intervertebral Disc: A Concise Review.
- Medicine, BiologyTissue engineering. Part B, Reviews
- 2021
Aim of this narrative review is to critically summarize current published evidence regarding particular aspects of IVD-TE, primarily emphasizing in providing researchers in this field with practicable knowledge in order to enhance clinical translatability of their research and informing clinical practitioners about the features and capabilities of innovative TE science in the field of IVd-TE.
Osteoporosis therapies might lead to intervertebral disc degeneration via affecting cartilage endplate.
- Biology, MedicineMedical hypotheses
- 2019
Adrenoceptor Expression during Intervertebral Disc Degeneration
- BiologyInternational journal of molecular sciences
- 2020
For the first time, the existence and functionality of ARs were demonstrated in IVD tissue samples, suggesting that the sympathicus might play a role in IVDD.
References
SHOWING 1-10 OF 108 REFERENCES
Histology and pathology of the human intervertebral disc.
- Biology, MedicineThe Journal of bone and joint surgery. American volume
- 2006
The intervertebral disc is a highly organized matrix laid down by relatively few cells in a specific manner that allows the discs to facilitate movement and flexibility within what would be an otherwise rigid spine.
Intervertebral Disc: Anatomy‐Physiology‐Pathophysiology‐Treatment
- Biology, MedicinePain practice : the official journal of World Institute of Pain
- 2008
The degenerative disc, having lost its height, effects the structures close by, such as ligamentum flavum, facet joints, and the shape of the neural foramina, the main cause of spinal stenosis and radicular pain due to the disc degeneration in the aged populations.
Temporo-spatial distribution of blood vessels in human lumbar intervertebral discs
- Biology, MedicineEuropean Spine Journal
- 2006
It is shown that vascular invasion deeper than the periphery was not observed during disc degeneration, which supports the hypothesis that vascular in-growth is not a distinct feature of disc degenerations.
Biochemical and Structural Properties of the Cartilage End-Plate and its Relation to the Intervertebral Disc
- Biology, MedicineSpine
- 1989
The biochemical and histologic properties of the end-plate and adjacent tissues in the young human adult lumbar spine are described and a datum is established in which to demonstrate variation with location and relationships between properties of different tissues.
Intervertebral disc changes with aging of human cervical vertebra. From the neonate to the eighties.
- Biology, MedicineSpine
- 1988
Both the calcification within the cartilaginous end-plate, accompanied by bone formation, and its superficial detachment, seems to destroy this layer and lead up to the obliteration of the disc.
Endplate calcification and cervical intervertebral disc degeneration: the role of endplate marrow contact channel occlusion.
- MedicineFolia morphologica
- 2015
There is a strong negative correlation between the number of endplate MCCs, and both macroscopic and microscopic cervical IVD and endplate degeneration, which could further support the thesis that endplate calcification, through the occlusion of Mccs, leads to a fall in nutrient transport to the IVD, and subsequently causes its degeneration.
Investigation of the Laminate Structure of Lumbar Disc Anulus Fibrosus
- MedicineSpine
- 1990
The structure of the lumbar disc anulus fibrosus was investigated using a layer-by-layer peeling technique and microscopic examination of various cut surfaces to identify mechanisms of layer interruption at local laminate irregularities.
The lumbar intervertebral disc: from embryonic development to degeneration.
- Biology, MedicineJoint, bone, spine : revue du rhumatisme
- 2014
Intervertebral disc degeneration: evidence for two distinct phenotypes
- BiologyJournal of anatomy
- 2012
The structural defects which initiate the two processes both act to decompress the disc nucleus, making it less likely that the other defect could occur subsequently, and in this sense the two disc degeneration phenotypes can be viewed as distinct.
Three-Dimensional Architecture of Lumbar Intervertebral Discs
- Biology, EngineeringSpine
- 1981
Three-dimensional observation of the collagen framework of lumbar intervertebral discs by scanning electron microscopy confirmed that the fibrillar framework of the annulus and the cartilage…