The biology behind the human intervertebral disc and its endplates.

@article{Tomaszewski2015TheBB,
  title={The biology behind the human intervertebral disc and its endplates.},
  author={Krzysztof A. Tomaszewski and Karolina Saganiak and Tomasz Gładysz and Jerzy A. Walocha},
  journal={Folia morphologica},
  year={2015},
  volume={74 2},
  pages={
          157-68
        }
}
The intervertebral discs (IVDs) are roughly cylindrical, fibrocartilaginous, articulating structures connecting the vertebral bodies, and allowing movement in the otherwise rigid anterior portion of the vertebral column. They also transfer loads and dissipate energy. Macroscopically the intervertebral disc can be divided into an outer annulus fibrosus surrounding a centrally located nucleus pulposus. The endplates surround the IVD from both the cranial and caudal ends, and separate them from… 

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References

SHOWING 1-10 OF 108 REFERENCES
Histology and pathology of the human intervertebral disc.
TLDR
The intervertebral disc is a highly organized matrix laid down by relatively few cells in a specific manner that allows the discs to facilitate movement and flexibility within what would be an otherwise rigid spine.
Intervertebral Disc: Anatomy‐Physiology‐Pathophysiology‐Treatment
  • P. Raj
  • Biology, Medicine
    Pain practice : the official journal of World Institute of Pain
  • 2008
TLDR
The degenerative disc, having lost its height, effects the structures close by, such as ligamentum flavum, facet joints, and the shape of the neural foramina, the main cause of spinal stenosis and radicular pain due to the disc degeneration in the aged populations.
Temporo-spatial distribution of blood vessels in human lumbar intervertebral discs
TLDR
It is shown that vascular invasion deeper than the periphery was not observed during disc degeneration, which supports the hypothesis that vascular in-growth is not a distinct feature of disc degenerations.
Biochemical and Structural Properties of the Cartilage End-Plate and its Relation to the Intervertebral Disc
TLDR
The biochemical and histologic properties of the end-plate and adjacent tissues in the young human adult lumbar spine are described and a datum is established in which to demonstrate variation with location and relationships between properties of different tissues.
Intervertebral disc changes with aging of human cervical vertebra. From the neonate to the eighties.
TLDR
Both the calcification within the cartilaginous end-plate, accompanied by bone formation, and its superficial detachment, seems to destroy this layer and lead up to the obliteration of the disc.
Endplate calcification and cervical intervertebral disc degeneration: the role of endplate marrow contact channel occlusion.
TLDR
There is a strong negative correlation between the number of endplate MCCs, and both macroscopic and microscopic cervical IVD and endplate degeneration, which could further support the thesis that endplate calcification, through the occlusion of Mccs, leads to a fall in nutrient transport to the IVD, and subsequently causes its degeneration.
Investigation of the Laminate Structure of Lumbar Disc Anulus Fibrosus
TLDR
The structure of the lumbar disc anulus fibrosus was investigated using a layer-by-layer peeling technique and microscopic examination of various cut surfaces to identify mechanisms of layer interruption at local laminate irregularities.
The lumbar intervertebral disc: from embryonic development to degeneration.
Intervertebral disc degeneration: evidence for two distinct phenotypes
TLDR
The structural defects which initiate the two processes both act to decompress the disc nucleus, making it less likely that the other defect could occur subsequently, and in this sense the two disc degeneration phenotypes can be viewed as distinct.
Three-Dimensional Architecture of Lumbar Intervertebral Discs
Three-dimensional observation of the collagen framework of lumbar intervertebral discs by scanning electron microscopy confirmed that the fibrillar framework of the annulus and the cartilage
...
1
2
3
4
5
...