The biology and pathology of the familial Parkinson's disease protein LRRK2.

Abstract

Parkinson's disease (PD) is typically a sporadic illness, but the past decade has witnessed the identification of mutations responsible for multiple familial forms of the disease. The proposed functions of some of these genes (e.g., E3 ubiquitin ligase, redox-dependent chaperone) have led to the hypothesis that dysfunction of protein quality control… (More)
DOI: 10.1002/mds.22717

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