The biology, pathology and therapeutic use of prostaglandins in the eye

  title={The biology, pathology and therapeutic use of prostaglandins in the eye},
  author={Carol B. Toris and Vikas Gulati},
  journal={Clinical Lipidology},
  pages={577 - 591}
Abstract Prostaglandins (PGs) are ubiquitous compounds found throughout the body, including the eye. They are involved in a variety of ocular functions, two of which are intraocular pressure (IOP) regulation and mediation of inflammation. Currently, PG analogs are the mainstay of topical IOP lowering therapy for glaucoma. The IOP effects of PGs are mediated by their actions on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases, thereby facilitating the outflow of… 
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Prostaglandin analogs have a different mechanism of action than other ocular hypotensives, and act primarily by increasing uveoscleral outflow, and have a substantial additive effect when used with agents that reduce aqueous production or that increase trabecular outflow facility.
Prostaglandins. Old concepts and new perspectives.
  • L. Bito
  • Medicine
    Archives of ophthalmology
  • 1987
Substantial evidence is provided that the intraocular pressure (IOP)-lowering effect of topically applied prostaglandin F2α(PGF2α) results from an increase in uveoscleral outflow.
Release of prostaglandins in ocular inflammation in the rabbit.
Uveitis was induced by a single intravitreal injection of a sterile solution of crystallized bovine serum albumin (British Drug Houses) and fine filaments were seen in the anterior chamber when uveitis occurred in the test eye.
The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice.
The prostanoid FP receptor plays a crucial role in the mechanism of early IOP lowering of all commercially available prostaglandin analogues as well as presumed functional uveoscleral outflow pathways in FPKO mice.
Metabolism of arachidonic acid in the retina and retinal pigment epithelium: biological effects of oxygenated metabolites of arachidonic acid.
  • N. Bazan
  • Biology, Medicine
    Progress in clinical and biological research
  • 1989
Evidence is presented indicating that eicosanoids can also be involved in retinal neurotransmission and cell to cell interaction, and an involvement of 5-lipoxygenase metabolites in the initial steps of ROS phagocytosis is presented.