The biological significance of nitric oxide formation from L-arginine.

@article{Moncada1989TheBS,
  title={The biological significance of nitric oxide formation from L-arginine.},
  author={Salvador Moncada and Richard M J Palmer and Ernest Higgs},
  journal={Biochemical Society transactions},
  year={1989},
  volume={17 4},
  pages={642-4}
}
The vascular endothelium synthesizes nitric oxide (NO) from the terminal guanidino nitrogen atom( s) of L-arginine. NO accounts for the biological actions of endotheliumderived relaxing factor (EDRF). It is becoming apparent that the synthesis of NO from L-arginine not only explains endothelium-dependent vascular relaxation, but is a widespread mechanism for the regulation of cell function and communication. The evidence for this so far derives from work on vascular endothelial cells… CONTINUE READING

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