The biological significance of nitric oxide formation from L-arginine.

  title={The biological significance of nitric oxide formation from L-arginine.},
  author={Salvador Moncada and Richard M J Palmer and Ernest Higgs},
  journal={Biochemical Society transactions},
  volume={17 4},
The vascular endothelium synthesizes nitric oxide (NO) from the terminal guanidino nitrogen atom( s) of L-arginine. NO accounts for the biological actions of endotheliumderived relaxing factor (EDRF). It is becoming apparent that the synthesis of NO from L-arginine not only explains endothelium-dependent vascular relaxation, but is a widespread mechanism for the regulation of cell function and communication. The evidence for this so far derives from work on vascular endothelial cells… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…